July 1987
Volume 28, Issue 7
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Articles  |   July 1987
Vitreous macrophage elicitation: generation of stimulants for pigment epithelium in vitro.
Investigative Ophthalmology & Visual Science July 1987, Vol.28, 1100-1107. doi:
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      J M Burke, S S Twining; Vitreous macrophage elicitation: generation of stimulants for pigment epithelium in vitro.. Invest. Ophthalmol. Vis. Sci. 1987;28(7):1100-1107.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Vitreous and macrophage samples were tested for the ability to stimulate proliferation and cell migration in cultured rabbit retinal pigment epithelium (RPE). A macrophage invasion was elicited by the intravitreal injection of latex particles in rabbits and after 3 days the vitreal macrophages were collected. The macrophages themselves, macrophage-conditioned culture medium, and macrophage-incubated vitreous had modest effects on RPE proliferation, but significantly stimulated RPE migration. A portion of the migration activity may be due to macrophage-derived proteases acting on normal vitreous. Mitogenic and additional migration-stimulating activity may also arise from adjacent tissues or from a breakdown of the blood-vitreous barrier that accompanies a macrophage invasion. A macrophage ingress into the vitreous may provide part of the stimulation for the migration and proliferation of RPE in conditions such as proliferative vitreoretinopathy.

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