December 1987
Volume 28, Issue 12
Free
Articles  |   December 1987
Retinal S-antigen in human subretinal fluid.
Author Affiliations
  • J Sebag
    Eye Research Institute of Retina Foundation, Harvard Medical School, Boston, Massachusetts.
  • V V Tuyen
    Eye Research Institute of Retina Foundation, Harvard Medical School, Boston, Massachusetts.
  • J P Faure
    Eye Research Institute of Retina Foundation, Harvard Medical School, Boston, Massachusetts.
  • D Chauvaud
    Eye Research Institute of Retina Foundation, Harvard Medical School, Boston, Massachusetts.
  • Y Pouliquen
    Eye Research Institute of Retina Foundation, Harvard Medical School, Boston, Massachusetts.
Investigative Ophthalmology & Visual Science December 1987, Vol.28, 2038-2041. doi:
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    • Get Citation

      J Sebag, V V Tuyen, J P Faure, D Chauvaud, Y Pouliquen; Retinal S-antigen in human subretinal fluid.. Invest. Ophthalmol. Vis. Sci. 1987;28(12):2038-2041.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Studies in experimental models of retinal detachment have proposed that the degree of visual recovery following retinal reattachment depends upon the extent of photoreceptor degeneration. A means of assessing this degeneration would help in establishing postoperative prognosis. S-antigen (S-Ag) is a unique retinal protein found in outer segment disc membranes and photoreceptor cells. In 36 cases of human rhegmatogenous retinal detachment, subretinal fluid (SRF) concentrations of S-Ag, measured by radioimmunoassay, ranged from 43 to 170 ng/ml (serum: 1-28 ng/ml). Analysis of variance showed a positive correlation with the duration of detachment (P less than 0.001). There was a two-fold increase in S-Ag concentrations during the first 2 weeks of detachment (P less than 0.005), with constant levels thereafter. These findings reflect progressive photoreceptor degeneration and/or ongoing synthesis of outer segment proteins in the detached retina that stop after the second week of detachment. SRF S-Ag levels may provide a prognostic indicator of visual recovery after reattachment as well as a sensitive measure of retinal metabolic activity during detachment.

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