July 1987
Volume 28, Issue 7
Free
Articles  |   July 1987
In situ immune complex formation within the uvea. Potential role of cationic antibody.
Investigative Ophthalmology & Visual Science July 1987, Vol.28, 1191-1195. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J C Waldrep, H J Kaplan, M Warbington; In situ immune complex formation within the uvea. Potential role of cationic antibody.. Invest. Ophthalmol. Vis. Sci. 1987;28(7):1191-1195.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

A murine model has been developed to study the role of immunoglobulin charge in the regulation of the intraocular distribution of circulating IgG antibodies. Intravenously injected cationic antibodies to the tracer enzyme horseradish peroxidase bind within the ciliary body and choroid (CB/Ch). These cationic antibodies can selectively entrap and bind circulating antigens forming immune complexes (IC) within the uveal tissues. The structure of the uvea with its fenestrated CB/Ch capillaries and fixed anionic sites (within Bruch's membrane and the stroma of the CB and processes) may predispose the CB/Ch to in situ IC formation. Local IC formation mediated initially by deposition of cationic antibodies within the uvea may play an important role in the immunopathogenesis of some forms of uveitis.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×