August 1987
Volume 28, Issue 8
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Articles  |   August 1987
Hereditary cataracts in the John Rapp inbred strain of Dahl salt-sensitive rat.
Investigative Ophthalmology & Visual Science August 1987, Vol.28, 1422-1428. doi:
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      C E Margo, E P Gomez-Sanchez, R Gstalder; Hereditary cataracts in the John Rapp inbred strain of Dahl salt-sensitive rat.. Invest. Ophthalmol. Vis. Sci. 1987;28(8):1422-1428.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Cataracts were apparently fixed in the genome of a highly inbred strain of Dahl salt-sensitive (S/JR) rat during the course of the selection for hypertension. Cataracts were present in S/JR rats inbred for more than 40 generations, but were not present in any of the salt-resistant rats (R/JR) inbred and observed during the same time. Light and electron microscopic evaluation of 11 pairs of S/JR rat lenses revealed a large posterior capsular defect and marked degenerative changes in lens fibers in each case. While the reason for the posterior capsular break is unclear, the cataract is probably a manifestation of an abnormal recessive gene or a recent autosomal dominant mutation.

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