November 1991
Volume 32, Issue 12
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Articles  |   November 1991
Intraocular and cardiovascular effects of calcitonin gene-related peptide (CGRP)-I and -II in the rabbit.
Author Affiliations
  • K Krootila
    Department of Anatomy, University of Helsinki, Finland.
  • H Uusitalo
    Department of Anatomy, University of Helsinki, Finland.
  • A Palkama
    Department of Anatomy, University of Helsinki, Finland.
Investigative Ophthalmology & Visual Science November 1991, Vol.32, 3084-3090. doi:
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      K Krootila, H Uusitalo, A Palkama; Intraocular and cardiovascular effects of calcitonin gene-related peptide (CGRP)-I and -II in the rabbit.. Invest. Ophthalmol. Vis. Sci. 1991;32(12):3084-3090.

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Abstract

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide localized in the eye in the sensory nerves. In this study, the physiological effects of the two naturally occurring forms of human CGRP, CGRP-I, and -II, which differ only in three amino acids, have been demonstrated in the rabbit eye and cardiovascular system. Intravenously administered CGRP-I caused a biphasic increase in the intraocular pressure (IOP), disruption of the blood-aqueous barrier, and increase in the cyclic adenosine 3',5'-monophosphate (cAMP) content in the aqueous humor. CGRP-II caused a monophasic increase in the IOP and disruption of the blood-aqueous barrier, but no increase in the cAMP content occurred. CGRP-I and -II decreased the blood pressure in a similar dose-dependent manner. The effects of intracamerally administered CGRP-I and -II were very similar in the eye. An increase in the IOP, breakdown of the blood-aqueous barrier, and an increase in the cAMP content in the aqueous humor occurred. The differences in the biological responses between CGRP-I and -II in the rabbit eye might be a result of the different affinities of the CGRP forms to a single receptor. Alternatively, different subtypes of receptors for CGRP-I and -II may exist in the rabbit.

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