March 1991
Volume 32, Issue 3
Free
Articles  |   March 1991
Effect of endothelin on outflow facility and accommodation in the monkey eye in vivo.
Author Affiliations
  • K Erickson-Lamy
    Department of Ophthalmology, and Neurology, Harvard Medical School, Boston, MA.
  • C Korbmacher
    Department of Ophthalmology, and Neurology, Harvard Medical School, Boston, MA.
  • J S Schuman
    Department of Ophthalmology, and Neurology, Harvard Medical School, Boston, MA.
  • J A Nathanson
    Department of Ophthalmology, and Neurology, Harvard Medical School, Boston, MA.
Investigative Ophthalmology & Visual Science March 1991, Vol.32, 492-495. doi:
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      K Erickson-Lamy, C Korbmacher, J S Schuman, J A Nathanson; Effect of endothelin on outflow facility and accommodation in the monkey eye in vivo.. Invest. Ophthalmol. Vis. Sci. 1991;32(3):492-495.

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Abstract

The effect of the vasoactive peptide, endothelin, on facility of outflow, accommodation, and pupil diameter was measured in the monkey eye in vivo. Endothelin increased the outflow facility 22-71% at approximate anterior chamber concentrations ranging from 10(-10)-10(-7) M. Endothelin-induced accommodation was modest but consistent and statistically significant ranging from 1.61 to a maximum of 2.43 diopters at 10(-9) M and 10(-7) M endothelin, respectively. No change in pupil diameter was noted with any of the administered doses. These data demonstrate an action of endothelin on outflow facility and, together with prior evidence indicating the presence of endothelin receptors on the ciliary muscle, suggest that, like cholinergic agonists, the observed effects of endothelin on outflow facility may be mediated, at least in part, through an action on the ciliary muscle.

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