December 1991
Volume 32, Issue 13
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Articles  |   December 1991
Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor.
Author Affiliations
  • T S Kern
    Department of Ophthalmology, University of Wisconsin-Madison, WI 53706-1532.
  • R L Engerman
    Department of Ophthalmology, University of Wisconsin-Madison, WI 53706-1532.
Investigative Ophthalmology & Visual Science December 1991, Vol.32, 3175-3177. doi:
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    • Get Citation

      T S Kern, R L Engerman; Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor.. Invest. Ophthalmol. Vis. Sci. 1991;32(13):3175-3177.

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Abstract

Galactitol and myo-inositol concentrations were measured in retinas, erythrocytes, and skeletal muscle of experimentally galactosemic dogs receiving a placebo or the aldose reductase inhibitor, sorbinil, for 5 yr. The concentration of galactitol was increased more than 30-fold in the retina and other tissues by galactosemia, and the increase was inhibited 90-96% in all tissues by sorbinil. The concentration of free myo-inositol was greater than normal in retinas of galactosemic dogs, and its concentration was not altered by the aldose-reductase inhibitor. The myo-inositol concentration likewise was greater than normal in the retinas of dogs that were diabetic for 2-4 months. The marked inhibition of polyol production and accumulation in the retina of sorbinil-treated galactosemic dogs was not associated with a comparable inhibition of retinopathy.

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