August 1991
Volume 32, Issue 9
Free
Articles  |   August 1991
Immunohistochemical properties of human optic nerve glioma. Evidence of type 1 astrocyte origin.
Author Affiliations
  • P E Cutarelli
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio.
  • U R Roessmann
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio.
  • R H Miller
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio.
  • C S Specht
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio.
  • H E Grossniklaus
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio.
Investigative Ophthalmology & Visual Science August 1991, Vol.32, 2521-2524. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P E Cutarelli, U R Roessmann, R H Miller, C S Specht, H E Grossniklaus; Immunohistochemical properties of human optic nerve glioma. Evidence of type 1 astrocyte origin.. Invest. Ophthalmol. Vis. Sci. 1991;32(9):2521-2524.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

The peroxidase-antiperoxidase method was used to study ten surgically obtained human optic nerve gliomas (pilocytic astrocytomas). All tissues were formalin fixed and paraffin embedded. Primary antisera included glial fibrillary acidic protein (GFAP), HNK-1 (type 1 astrocyte precursor marker), A2B5 (type 2 astrocyte precursor marker), S-100, vimentin, myelin basic protein (MBP), laminin, keratin, cytokeratin, epithelial membrane antigen (EMA), and neuron-specific enolase (NSE). Neoplastic astrocytes in optic nerve gliomas stained with GFAP, HNK-1, S-100, and vimentin. Oligodendrocytes and myelin sheaths stained for MBP, and NSE stained surviving axons in the tumors. Neoplastic astrocytes did not stain for A2B5, keratin, cytokeratin, EMA, or laminin. These results suggest that human optic nerve gliomas (pilocytic astrocytomas) arise from type 1 astrocytes.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×