November 1991
Volume 32, Issue 12
Free
Articles  |   November 1991
Magnetic resonance imaging of the rabbit eye. Improved anatomical detail using magnetization transfer contrast.
Author Affiliations
  • T L Ceckler
    National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
  • K Karino
    National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
  • P F Kador
    National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
  • R S Balaban
    National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
Investigative Ophthalmology & Visual Science November 1991, Vol.32, 3109-3113. doi:
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    • Get Citation

      T L Ceckler, K Karino, P F Kador, R S Balaban; Magnetic resonance imaging of the rabbit eye. Improved anatomical detail using magnetization transfer contrast.. Invest. Ophthalmol. Vis. Sci. 1991;32(12):3109-3113.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Proton nuclear magnetic resonance (NMR) imaging previously has been used to examine structure and pathologies of the eye. The present study investigates the use of a saturation-transfer technique, which exploits water-macromolecular proton magnetic interactions, to enhance image contrast in the rabbit eye in vivo. Upon steady-state saturation of the macromolecular-proton magnetization, the water-proton signal intensity will decrease in proportion to the degree of water-macromolecular proton magnetic interaction. NMR images of the eye collected using saturation transfer are shown to have superior contrast compared to conventional NMR imaging techniques, in regard to numerous ocular structures, including the iris, ciliary bodies, muscle, lens, and cornea.

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