August 1990
Volume 31, Issue 8
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Articles  |   August 1990
Evaluation of an iris color classification system. The Eye Disorders Case-Control Study Group.
Author Affiliations
  • J M Seddon
    Massachusetts Eye and Ear Infirmary, Epidemiology Unit, Boston 02114.
  • C R Sahagian
    Massachusetts Eye and Ear Infirmary, Epidemiology Unit, Boston 02114.
  • R J Glynn
    Massachusetts Eye and Ear Infirmary, Epidemiology Unit, Boston 02114.
  • R D Sperduto
    Massachusetts Eye and Ear Infirmary, Epidemiology Unit, Boston 02114.
  • E S Gragoudas
    Massachusetts Eye and Ear Infirmary, Epidemiology Unit, Boston 02114.
Investigative Ophthalmology & Visual Science August 1990, Vol.31, 1592-1598. doi:
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      J M Seddon, C R Sahagian, R J Glynn, R D Sperduto, E S Gragoudas; Evaluation of an iris color classification system. The Eye Disorders Case-Control Study Group.. Invest. Ophthalmol. Vis. Sci. 1990;31(8):1592-1598.

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      © 2015 Association for Research in Vision and Ophthalmology.

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A system for classification of iris color based on standard photographs, developed for use in a multicenter study, is described. Categories of iris color are distinguished based on predominant color (blue, gray, green, light brown, or brown) and the amount of brown or yellow pigment present in the iris. Two trained readers independently graded 339 iris photographs; discrepancies in grades were adjudicated. Measures of interobserver reliability were 0.76 by kappa for exact agreement and 0.97 for weighted kappa. The distribution of iris color grades demonstrates that the system achieved an appropriate level of detail within the authors' study population, which included patients with various racial backgrounds from five urban clinical centers. This simple, reliable classification system for iris color is offered for use in clinical research.

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