January 1990
Volume 31, Issue 1
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Articles  |   January 1990
Pathologic changes in the exorbital lacrimal gland of the vitamin A-deficient rat.
Author Affiliations
  • K Hayashi
    Eye Research Institute of Retina Foundation, Boston, MA 02114.
  • C Reddy
    Eye Research Institute of Retina Foundation, Boston, MA 02114.
  • L Hanninen
    Eye Research Institute of Retina Foundation, Boston, MA 02114.
  • G Wolf
    Eye Research Institute of Retina Foundation, Boston, MA 02114.
  • K R Kenyon
    Eye Research Institute of Retina Foundation, Boston, MA 02114.
Investigative Ophthalmology & Visual Science January 1990, Vol.31, 187-196. doi:
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    • Get Citation

      K Hayashi, C Reddy, L Hanninen, G Wolf, K R Kenyon; Pathologic changes in the exorbital lacrimal gland of the vitamin A-deficient rat.. Invest. Ophthalmol. Vis. Sci. 1990;31(1):187-196.

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Abstract

Histologic changes in lacrimal glands of vitamin A-deficient (A-) and pair-fed control rats were compared. In A- lacrimal glands, secretory granules were strikingly diminished, and rough endoplasmic reticulum appeared somewhat atrophic. Nuclei of acinar cells were hyperchromatic and pleomorphic. Using alcian blue-PAS, no positive staining was present in acini of A- lacrimal glands, whereas in controls apical portions of acini were intensely stained. Thus, lacrimal tissues of A- rats were thought to be poorly differentiated as a glandular epithelium. When A- rats were supplemented with retinyl acetate, secretory granules reappeared, rough endoplasmic reticulum cisternae greatly dilated, and mitochondria proliferated, indicating accelerated secretory activity. Resupply of vitamin A can induce glandular differentiation in A- lacrimal tissues. Tear volume was not decreased in A- rats compared with pair-fed controls. Regression of secretory organelles in A- lacrimal tissues may lead to a decrease in protein and mucoprotein secretion and subsequent changes in tear composition.

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