December 1991
Volume 32, Issue 13
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Articles  |   December 1991
In vivo fibroplasia of a porous polymer in the cornea.
Author Affiliations
  • V Trinkaus-Randall
    Boston University School of Medicine, Massachusetts.
  • R Banwatt
    Boston University School of Medicine, Massachusetts.
  • J Capecchi
    Boston University School of Medicine, Massachusetts.
  • H M Leibowitz
    Boston University School of Medicine, Massachusetts.
  • C Franzblau
    Boston University School of Medicine, Massachusetts.
Investigative Ophthalmology & Visual Science December 1991, Vol.32, 3245-3251. doi:
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    • Get Citation

      V Trinkaus-Randall, R Banwatt, J Capecchi, H M Leibowitz, C Franzblau; In vivo fibroplasia of a porous polymer in the cornea.. Invest. Ophthalmol. Vis. Sci. 1991;32(13):3245-3251.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

We have developed a melt-blown fibrous construction of polybutylene/polypropylene in which we previously demonstrated keratocyte ingrowth and collagen synthesis in vitro. In the present studies, we evaluated this material in vivo in interlamellar corneal pockets for periods of up to six months. By day 42, the porous interstices of the disc were heavily populated with keratocytes. Extracellular matrix deposition occurred and there was a 5000-fold increase in total protein and a 1000-fold increase in total collagen over background. The cells within the disc continued to be synthetically active for the six months of our study. Discs remained in corneas for periods of up to one year without any extrusion. This material has great promise as a porous peripheral component of a keratoprosthetic device.

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