August 1991
Volume 32, Issue 9
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Articles  |   August 1991
The effects of the fluorinated pyrimidines FUR, FUdR, FUMP, and FdUMP on human Tenon's fibroblasts.
Author Affiliations
  • D A Lee
    University of California, Jules Stein Eye Institute, Los Angeles 90024-7004.
  • S Shapourifar-Tehrani
    University of California, Jules Stein Eye Institute, Los Angeles 90024-7004.
  • T R Stephenson
    University of California, Jules Stein Eye Institute, Los Angeles 90024-7004.
  • S Kitada
    University of California, Jules Stein Eye Institute, Los Angeles 90024-7004.
Investigative Ophthalmology & Visual Science August 1991, Vol.32, 2599-2609. doi:
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      D A Lee, S Shapourifar-Tehrani, T R Stephenson, S Kitada; The effects of the fluorinated pyrimidines FUR, FUdR, FUMP, and FdUMP on human Tenon's fibroblasts.. Invest. Ophthalmol. Vis. Sci. 1991;32(9):2599-2609.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

5-Fluorouracil (5-FU) has effectively inhibited fibroblast proliferation to prevent scar formation and bleb failure after glaucoma filtering surgery. To identify more potent but less toxic antiproliferative drugs, the authors studied cell attachment and proliferation of 5-FU metabolites: 5-fluorouridine (FUR), 5-fluorodeoxyuridine (FUdR), 5-fluorouridine-5'-monophosphate (FUMP), and 5-fluorodeoxyuridine-5'-monophosphate (FdUMP) on human Tenon's fibroblasts in vitro.

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