March 1991
Volume 32, Issue 3
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Articles  |   March 1991
A 52 kD cytoskeletal protein from retinal rod photoreceptors is related to erythrocyte dematin.
Author Affiliations
  • D Roof
    Berman-Gund Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
  • A Hayes
    Berman-Gund Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
  • G Hardenbergh
    Berman-Gund Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
  • M Adamian
    Berman-Gund Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
Investigative Ophthalmology & Visual Science March 1991, Vol.32, 582-593. doi:
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      D Roof, A Hayes, G Hardenbergh, M Adamian; A 52 kD cytoskeletal protein from retinal rod photoreceptors is related to erythrocyte dematin.. Invest. Ophthalmol. Vis. Sci. 1991;32(3):582-593.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A novel cytoskeletal antigen, RET52, has been identified in the mouse retina. This 52 kD polypeptide is antigenically related to dematin (band 4.9), an actin-bundling phosphoprotein component of the erythrocyte membrane skeleton. Like dematin, RET52 is also a substrate for cAMP-dependent protein kinase. Within the retina, RET52 is primarily concentrated in two regions-the rod inner segment and the outer synaptic layers-although the developmental expression of RET52 differs in these areas. RET52 is present at birth in the inner segment, but appears about the time of initial synapse formation (postnatal day 4-6) in the outer plexiform layer. No differences in RET52 expression have been detected in early-stage mouse retinas with the retinal degeneration (rd) phenotype. RET52 localization, developmental expression, homologies to dematin, and in vitro phosphorylation pattern suggest a possible role for cytoskeleton-associated proteins in the initiation or control of disk membrane assembly and/or synapse formation in the rod photoreceptor.

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