February 1994
Volume 35, Issue 2
Free
Articles  |   February 1994
Cortical lenticular opacification: distribution and location in a longitudinal study.
Author Affiliations
  • O D Schein
    Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • S West
    Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • B Muñoz
    Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • S Vitale
    Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • M Maguire
    Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • H R Taylor
    Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • N M Bressler
    Dana Center for Preventive Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Investigative Ophthalmology & Visual Science February 1994, Vol.35, 363-366. doi:
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      O D Schein, S West, B Muñoz, S Vitale, M Maguire, H R Taylor, N M Bressler; Cortical lenticular opacification: distribution and location in a longitudinal study.. Invest. Ophthalmol. Vis. Sci. 1994;35(2):363-366.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To examine the distribution of cortical opacification of the lens by lens quadrant in a longitudinal study. METHODS: In 1990, a follow-up assessment of a cohort of Chesapeake Bay watermen, initially studied in 1985, was performed. Four hundred thirty-seven subjects (834 eyes) had gradable cortical photographs for at least one eye in both 1985 and 1990. Cortical photographs were graded by both estimating total area and determining the quadrant with the greatest degree of cortical opacification. RESULTS: The prevalence and severity of cortical opacification increased with age with a high degree of concordance (84%) between eyes. For the 47 eyes with cortical opacification > or = 1/8 at baseline, the principal locations of opacification were: inferonasal 63.8%, inferotemporal 17.0%, superonasal 6.4%, and superotemporal 12.8% (P < 0.001, compared with equal distribution by quadrant). Five-year development of new cortical opacification and five-year progression of existing cortical opacification showed even greater preferential occurrence in the inferonasal quadrant of the lens. CONCLUSIONS: In this population, the inferonasal quadrant of the lens is the principal site of cortical opacification in both cross-sectional and longitudinal assessment. This finding is consistent with the hypothesis that sunlight exposure is a significant risk factor for cortical opacification.

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