November 1995
Volume 36, Issue 12
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Articles  |   November 1995
Prostaglandin F2 alpha effects on isolated rhesus monkey ciliary muscle.
Author Affiliations
  • J F Poyer
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison 53792-3220, USA.
  • C Millar
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison 53792-3220, USA.
  • P L Kaufman
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison 53792-3220, USA.
Investigative Ophthalmology & Visual Science November 1995, Vol.36, 2461-2465. doi:
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    • Get Citation

      J F Poyer, C Millar, P L Kaufman; Prostaglandin F2 alpha effects on isolated rhesus monkey ciliary muscle.. Invest. Ophthalmol. Vis. Sci. 1995;36(12):2461-2465.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: The effects of prostaglandin (PG)F2 alpha on the contractile response in the longitudinal and coronal vectors of the isolated rhesus monkey ciliary muscle were studied. METHODS: Fresh rhesus monkey ciliary muscle strips from young and middle-aged animals were mounted in an apparatus capable of monitoring contractile force simultaneously in the two vectors. The responses to PGF2 alpha were measured and compared to those produced with 1 microM carbachol. RESULTS: PGF2 alpha consistently relaxed the carbachol precontracted ciliary muscle in a dose-dependent manner with equal potency and efficacy in both vectors, but it did not alter the tone of muscle strips at resting tension. CONCLUSIONS: The relaxation of precontracted ciliary muscle by PGF2 alpha may help explain how a single topical dose of this prostanoid increases uveoscleral outflow and antagonizes resting myopia in the living monkey.

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