September 1995
Volume 36, Issue 10
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Articles  |   September 1995
Effect of prior oxygen exposure on the electroretinographic responses of infant rats.
Author Affiliations
  • X Reynaud
    Department of Ophthalmology, Childen's Hospitalk, Boston, MA 02115, USA.
  • R M Hansen
    Department of Ophthalmology, Childen's Hospitalk, Boston, MA 02115, USA.
  • A B Fulton
    Department of Ophthalmology, Childen's Hospitalk, Boston, MA 02115, USA.
Investigative Ophthalmology & Visual Science September 1995, Vol.36, 2071-2079. doi:
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      X Reynaud, R M Hansen, A B Fulton; Effect of prior oxygen exposure on the electroretinographic responses of infant rats.. Invest. Ophthalmol. Vis. Sci. 1995;36(10):2071-2079.

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Abstract

PURPOSE: To study electroretinographic responses of infant rats with a history of exposure to high-ambient oxygen. METHODS: Electroretinographic responses to a range of full-field stimuli were recorded from 13-day-old (n = 8) and 18-day-old (n = 10) rats with a history of intermittent exposure to 80% oxygen and age-matched controls. The a-waves were fitted with a model of rod cell sensitivity and saturated response amplitude. The amplitudes and implicit times of the b-wave and oscillatory wavelets were examined as a function of stimulus energy. Response parameters in oxygen-exposed rats were compared to those in controls. RESULTS: The amplitude of the saturated rod response was reduced in oxygen-exposed 13-day-old but not 18-day-old rats. The sensitivity of the rod response was reduced in both 13- and 18-day-old oxygen-exposed rats. The saturated amplitude and sensitivity of the b-wave did not differ significantly between oxygen-exposed and control rats age 13 days, but both amplitude and sensitivity were significantly decreased in 18-day-old oxygen-exposed rats. Oscillatory potentials, which could be investigated only in 18-day-old rats, showed significant attenuation of OP3 but not OP4 amplitudes in the oxygen-exposed rats. The sensitivity of OP2 did not differ significantly between oxygen-exposed and control rats. The avascular area in the oxygen-exposed rats was not correlated with any of the rod cell, b-wave, or oscillatory potential response parameters. CONCLUSION: The function of the rod photoreceptors, as well as the inner retina, is altered in infant rats with a history of oxygen exposure.

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