May 1995
Volume 36, Issue 6
Free
Articles  |   May 1995
Cold stress-induced recurrences of herpetic keratitis in the squirrel monkey.
Author Affiliations
  • E D Varnell
    LSU Eye Center, New Orleans 70112, USA.
  • H E Kaufman
    LSU Eye Center, New Orleans 70112, USA.
  • J M Hill
    LSU Eye Center, New Orleans 70112, USA.
  • H W Thompson
    LSU Eye Center, New Orleans 70112, USA.
Investigative Ophthalmology & Visual Science May 1995, Vol.36, 1181-1183. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      E D Varnell, H E Kaufman, J M Hill, H W Thompson; Cold stress-induced recurrences of herpetic keratitis in the squirrel monkey.. Invest. Ophthalmol. Vis. Sci. 1995;36(6):1181-1183.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

PURPOSE: Models of recurrent herpetic keratitis that depend on tissue damage or immunosuppression have been described. The authors report a model that depends only on minimal temperature stress to produce clinical recurrences in a small primate. METHODS: Squirrel monkeys (Saimiri sciureus) infected by the ocular route with the Rodanus strain of herpesvirus type 1 (HSV-1) were exposed to temperatures approximately 5 degrees C lower than the usual ambient temperature for periods as short as 12 hours. RESULTS: The corneas showed more or larger lesions typical of recurrent herpetic keratitis than are usually seen in these animals under normal conditions. Statistical analysis showed that there were significantly higher frequencies of epithelial keratitis at 18 degrees C and 20 degrees C (P < 0.0001). CONCLUSIONS: A minimal temperature change produced significant recurrences in this small animal within a short time. Tissues were not damaged to produce the recurrences. This approach may provide an efficient primate model for rapid testing of drugs to prevent clinical recurrence of ocular herpetic keratitis.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×