February 1994
Volume 35, Issue 2
Free
Articles  |   February 1994
Recombinant tissue inhibitor of metalloproteinases type 1 suppresses alkali-burn-induced corneal ulceration in rabbits.
Author Affiliations
  • C A Paterson
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Research Institute, University of Louisville School of Medicine 40292.
  • J G Wells
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Research Institute, University of Louisville School of Medicine 40292.
  • P A Koklitis
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Research Institute, University of Louisville School of Medicine 40292.
  • G A Higgs
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Research Institute, University of Louisville School of Medicine 40292.
  • A J Docherty
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Research Institute, University of Louisville School of Medicine 40292.
Investigative Ophthalmology & Visual Science February 1994, Vol.35, 677-684. doi:
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    • Get Citation

      C A Paterson, J G Wells, P A Koklitis, G A Higgs, A J Docherty; Recombinant tissue inhibitor of metalloproteinases type 1 suppresses alkali-burn-induced corneal ulceration in rabbits.. Invest. Ophthalmol. Vis. Sci. 1994;35(2):677-684.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To test if recombinant tissue inhibitor of metalloproteinases (TIMP-1) was effective in reducing corneal ulceration after alkali injury to the rabbit cornea. The effect of TIMP-1 was compared with that of a proven synthetic metalloproteinase inhibitor. METHODS: After a defined alkali injury to the rabbit cornea, a topical treatment regimen was followed for 24 days; one group was treated with vehicle only, a second group with recombinant TIMP-1, and a third group with the synthetic metalloproteinase inhibitor. Corneas were scored for ulceration during the 24-day period and the scores for the three groups were compared. RESULTS: The incidence and progression of ulceration and perforation, in the alkali-burned corneas receiving treatment with recombinant TIMP-1 or the synthetic inhibitor, were significantly less than in corneas receiving vehicle treatment alone. CONCLUSION: Recombinant TIMP-1 is as effective as a proven synthetic inhibitor in ameliorating corneal ulceration and perforation after an alkali injury.

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