May 1998
Volume 39, Issue 6
Free
Articles  |   May 1998
Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice.
Author Affiliations
  • S W John
    Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • R S Smith
    Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • O V Savinova
    Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • N L Hawes
    Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • B Chang
    Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • D Turnbull
    Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • M Davisson
    Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • T H Roderick
    Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • J R Heckenlively
    Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Investigative Ophthalmology & Visual Science May 1998, Vol.39, 951-962. doi:
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    • Get Citation

      S W John, R S Smith, O V Savinova, N L Hawes, B Chang, D Turnbull, M Davisson, T H Roderick, J R Heckenlively; Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice.. Invest. Ophthalmol. Vis. Sci. 1998;39(6):951-962.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To characterize ocular abnormalities associated with iris atrophy in DBA/2J mice and to determine whether mice of this strain develop elevated intraocular pressure (IOP) and glaucoma. METHODS: Different approaches, including slit-lamp biomicroscopy, ophthalmoscopic examination, ultrasound backscatter microscopy, and histology were used to examine the eyes of DBA/2J mice ranging from 2 to 30 months old. IOP was measured in DBA/2J mice of different ages. RESULTS: DBA/2J mice were found to develop pigment dispersion, iris transillumination, iris atrophy, anterior synechias, and elevated IOP. IOP was elevated in most mice by the age of 9 months. These changes were followed by the death of retinal ganglion cells, optic nerve atrophy, and optic nerve cupping. The prevalence and severity of these lesions increased with age. Optic nerve atrophy and optic nerve cupping was present in the majority of mice by the age of 22 months. CONCLUSIONS: DBA/2J mice develop a progressive form of secondary angle-closure glaucoma that appears to be initiated by iris atrophy and the associated formation of synechias. This mouse strain represents a useful model to evaluate mechanisms of pressure-related ganglion cell death and optic nerve atrophy, and to evaluate strategies for neuroprotection.

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