July 1995
Volume 36, Issue 8
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Articles  |   July 1995
Effects of ornithine on the electroretinogram in cat retina.
Author Affiliations
  • K Hiroi
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • F Yamamoto
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
  • Y Honda
    Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Investigative Ophthalmology & Visual Science July 1995, Vol.36, 1732-1737. doi:
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      K Hiroi, F Yamamoto, Y Honda; Effects of ornithine on the electroretinogram in cat retina.. Invest. Ophthalmol. Vis. Sci. 1995;36(8):1732-1737.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To study the acute effects of L-ornithine hydrochloride on the function of cat retina in vivo. METHODS: A small amount of ornithine was administered intravitreously or intravenously. Changes in retinal function were monitored by vitreal electroretinogram (ERG) and intraretinal ERG with K(+)-selective microelectrodes. RESULTS: Intravitreal injections (0.2 to 0.5 M; 15 microliters) of ornithine caused a decrease in the standing potential and the vitreal ERG c-wave amplitude. The ERG c-wave decreased continuously during a 5-hour period. Intravenous injection (0.2 M; 10 ml) of ornithine also diminished the c-wave. Intraretinal recording showed that the amplitudes of the retinal pigment epithelium (RPE) component and the Müller cell component of the ERG c-wave were reduced after intravitreal injection. The light-evoked [K+]o decrease in the subretinal space did not change. The change in transepithelial resistance contributed little to the decrease in the c-wave. CONCLUSION: These results demonstrated that ornithine selectively affects the c-wave and suggested that it affects RPE and Müller cells directly without affecting photoreceptors.

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