April 1997
Volume 38, Issue 5
Free
Articles  |   April 1997
Intercellular adhesion molecule-1 in proliferative vitreoretinopathy.
Author Affiliations
  • G A Limb
    Department of Immunology, St. Thomas' Hospital, UMDS, London, England.
  • A H Chignell
    Department of Immunology, St. Thomas' Hospital, UMDS, London, England.
  • C J Cole
    Department of Immunology, St. Thomas' Hospital, UMDS, London, England.
  • W T Green
    Department of Immunology, St. Thomas' Hospital, UMDS, London, England.
  • L Webster
    Department of Immunology, St. Thomas' Hospital, UMDS, London, England.
  • R D Hollifield
    Department of Immunology, St. Thomas' Hospital, UMDS, London, England.
  • D C Dumonde
    Department of Immunology, St. Thomas' Hospital, UMDS, London, England.
Investigative Ophthalmology & Visual Science April 1997, Vol.38, 1043-1048. doi:
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    • Get Citation

      G A Limb, A H Chignell, C J Cole, W T Green, L Webster, R D Hollifield, D C Dumonde; Intercellular adhesion molecule-1 in proliferative vitreoretinopathy.. Invest. Ophthalmol. Vis. Sci. 1997;38(5):1043-1048.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

PURPOSE: To measure vitreous levels of the soluble intercellular adhesion molecule (sICAM-1) in eyes with rhegmatogenous retinal detachment (RRD) complicated or uncomplicated by proliferative vitreoretinopathy (PVR) to investigate whether levels of this molecule related to history of previous retinal surgery or to the duration and severity of PVR. METHODS: The authors measured vitreous sICAM-1 by enzyme-linked immunosorbent assay in 28 eyes with PVR and 35 eyes with uncomplicated RRD. Vitreous from 10 eyes with macular holes and from 12 cadaveric eye donors were used as control specimens. RESULTS: Vitreous sICAM-1 levels were higher in the group with RRD complicated by PVR as a whole than in the group with RRD alone or in the control groups. In patients with no previous retinal surgery, there was no difference in vitreous sICAM-1 levels between the groups with RRD alone and RRD complicated by PVR. However, in patients who had undergone previous external surgery, those with PVR showed higher levels of vitreous sICAM-1 than those with RRD alone. In PVR, raised levels of sICAM-1 were associated preferentially with a history of previous vitrectomy as well as with a longer duration of the condition, although these levels were not related to the grade of PVR. In eyes with RRD alone, the levels of sICAM-1 were not enhanced with the duration of the detachment. Despite showing high vitreous levels of sICAM-1, patients with PVR did not exhibit increased serum levels of this adhesion molecule. CONCLUSIONS: The current observations suggest that those persons in whom PVR develops may have an impairment of the mechanisms that control the inflammatory response to retinal trauma. Persistently raised vitreous levels of sICAM-1 point to the continued operation of cytokine-mediated vascular reactions at the blood-retinal barrier.

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