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Jane Gwiazda, Wendy L. Marsh-Tootle, Leslie Hyman, Mohamed Hussein, Thomas T. Norton, the COMET Study Group; Baseline Refractive and Ocular Component Measures of Children Enrolled in the Correction of Myopia Evaluation Trial (COMET). Invest. Ophthalmol. Vis. Sci. 2002;43(2):314-321.
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purpose. To describe baseline refractive and ocular component measures in
children with myopia enrolled in the Correction of Myopia Evaluation
Trial (COMET). COMET is a multicenter, randomized clinical trial to
evaluate whether progressive-addition lenses slow the progression of
juvenile-onset myopia compared with single-vision lenses.
methods. Four hundred sixty-nine children with myopia between −1.25 and −4.50
D spherical equivalent and without eye or systemic conditions known to
affect refractive development were recruited from four geographically
and ethnically diverse communities in the United States. Their ages
were 6 to 11 years inclusive, and 52% were girls. The main outcome
measure for the overall trial is progression of myopia determined by
cycloplegic autorefraction after inducement of cycloplegia with
2 drops of 1% tropicamide. Axial length, the secondary outcome
measure, was assessed by ultrasonography. The distance correction was
determined by subjective methods before cycloplegia, with
noncycloplegic autorefraction values as the starting point.
results. Because data were similar in both eyes, they are reported for the right
eye only. The mean spherical equivalent measured by cycloplegic
autorefraction was −2.38 ± 0.81 D. Young children had
significantly less myopia than older children (P =
0.03), but the amount of myopia did not differ by gender or ethnicity.
Mean axial dimensions were 4.0 ± 0.2 mm (anterior chamber),
3.4 ± 0.2 mm (lens), 16.8 ± 0.7 mm (vitreous chamber), and
24.1 ± 0.7 mm (axial length). Girls’ eyes had significantly
shorter axial length than boys’ (P < 0.0001).
Mean corneal radii were 7.73 ± 0.25 mm (horizontal) and 7.59 ± 0.24 mm (vertical). Ninety-five percent of the eyes had a ratio of
axial length to corneal radius higher than 3.0.
conclusions. These baseline measures provide cross-sectional data on a large group
of ethnically diverse children with myopia. Refractive and axial
component dimensions are consistent with data in other studies showing
that myopic eyes have longer vitreous chambers than emmetropic eyes.
The measures reported herein will serve as a basis for examining
changes that occur over a minimum of 3 years of follow-up of
children enrolled in COMET.
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