Purchase this article with an account.
Lies Remeijer, Jeroen Maertzdorf, Johannes Buitenwerf, Albert D. M. E. Osterhaus, Georges M. G. M. Verjans; Corneal Herpes Simplex Virus Type 1 Superinfection in Patients with Recrudescent Herpetic Keratitis. Invest. Ophthalmol. Vis. Sci. 2002;43(2):358-363.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
purpose. Herpetic keratitis is a common sequel of a corneal infection with
herpes simplex virus (HSV)-1. Recrudescent herpetic keratitis (RHK) may
result in irreversible damage to the cornea. Recurrences may be caused
by reactivation of endogenous HSV-1 or reinfection with exogenous
HSV-1. The objective of this study was to determine the incidence and
risk factors involved of HSV-1 superinfection in patients with RHK.
methods. From 30 patients with RHK, sequential corneal HSV-1 isolates were
genotyped by PCR amplification of the hypervariable regions located
within the HSV-1 genes US1, US10/11, and US12. The clinical data from the patients obtained
retrospectively were: ophthalmologic history, clinical picture during
recurrences, number and time points of penetrating keratoplasty (PKP),
and steroid or acyclovir treatment.
results. Whereas the sequential corneal HSV-1 isolates of 19 (63%) of 30
patients had the same genotype (designated as group 1), the sequential
isolates of 11 patients (37%) were genetically different (designated
as group 2). Among the clinical data analyzed, only the time point of
PKP was significantly different between the patient groups. Although no
patients in group 1 had undergone transplantation between samplings, 4
of 11 patients in group 2 underwent PKP during the inter-recurrence
period in the same eye from which the corneal HSV-1 isolates were
conclusions. The data demonstrate that RHK is frequently associated with corneal
reinfection with a different HSV-1 strain and suggest that PKP is a
risk factor for corneal HSV-1 superinfection.
This PDF is available to Subscribers Only