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Teddy Maddess, Andrew Charles James, Ivan Goldberg, Stephen Wine, Jeffrey Dobinson; Comparing a Parallel PERG, Automated Perimetry, and Frequency-Doubling Thresholds. Invest. Ophthalmol. Vis. Sci. 2000;41(12):3827-3832.
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purpose. A pattern electroretinogram (PERG) simultaneously displaying the
frequency-doubling (FD) illusion in nine parts of the visual field was
compared with two other methods for ability to detect glaucoma. This
multiregion FD PERG (MFP) was compared with results from achromatic
automated perimetry and psychophysical tests using FD stimuli.
methods. MFP data were compared with that from the Humphrey Field Analyser (HFA;
Humphrey, San Leandro, CA) 24-2 program. Contrast thresholds were also
determined in different visual field locations for FD stimuli.
Thin-plate spline methods were used to derive comparisons from the
tests, each of which sampled the visual field differently.
results. Significant correlation with HFA could be obtained, providing seven to
nine (of nine) MFP amplitudes were themselves significant. Evidence
showed that both the psychophysical tests using FD stimuli and the MFP
detect glaucomatous damage not detected by the HFA.
conclusions. The comparisons between HFA perimetry, the MFP, and FD thresholds
indicate that both FD-based tests quantify a form of diffuse loss in
early glaucoma as well as the scotomas of later
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