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Teddy Maddess, Andrew Charles James, Ivan Goldberg, Stephen Wine, Jeffrey Dobinson; A Spatial Frequency-Doubling Illusion-Based Pattern Electroretinogram for Glaucoma. Invest. Ophthalmol. Vis. Sci. 2000;41(12):3818-3826.
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purpose. A pattern electroretinogram (PERG) in which stimuli displaying the
frequency-doubling (FD) illusion are presented simultaneously to
multiple parts of the visual field was evaluated for its ability to
diagnose glaucoma. This multiregion FD PERG is referred to in the
current study as the MFP.
methods. The nine stimulus regions were temporally modulated at incommensurate
frequencies typically producing an FD percept. Two other spatial scales
of the stimuli were also investigated. The sensitivity and specificity
of MFP were examined using linear and quadratic discriminant methods.
results. Even with the simpler linear discriminant classification, sensitivities
and specificities of 100% were obtained in eyes with moderate to
severe glaucoma. Of eyes with glaucoma strongly suspected, 67% were
classified as being glaucomatous. Stimulus patterns having differing
spatial scales produced different PERG visual field dependencies.
conclusions. The differing results for the 16-fold change in spatial scale may
reflect the accessing of different mechanisms. The MFP method appears
to have significant value for the diagnosis of
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