February 1965
Volume 4, Issue 1
Free
Articles  |   February 1965
The Efflux of 86Rubidium from the Rabbit Lens
Author Affiliations
  • BERNARD BECKER
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine St. Louis, Mo.
  • EDWARD COTLIER
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine St. Louis, Mo.
Investigative Ophthalmology & Visual Science February 1965, Vol.4, 117-121. doi:
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      BERNARD BECKER, EDWARD COTLIER; The Efflux of 86Rubidium from the Rabbit Lens. Invest. Ophthalmol. Vis. Sci. 1965;4(1):117-121.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Rabbit lenses which had accumulated 86Rb were incubated in a medium containing sufficient nonlabeled rubidium (33 mM.) to saturate the carrier or concentrations of ouabain (10-4M) which inhibited the transport system. The rate of runout of 86Rb so determined could be increased by reducing the concentration of calcium in the medium or by the addition of such metabolic inhibitors as iodoacetate, fiuoride, and cyanide. Several corticosteroids which did not alter 86Rb uptake did increase its efflux. Decapsulation of the lens with collagenase failed to alter 86Rb uptake or runout.

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