February 1965
Volume 4, Issue 1
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Articles  |   February 1965
Lens Assays on Diabetic and Galactosemic Rats receiving Diets that modify Cataract Development
Author Affiliations
  • JOHN W. PATTERSON
    School of Medicine, University of Connecticut Storrs, Conn., Kresge Eye Institute Detroit, Mich.
  • MARGARETTA E. PATTERSON
    School of Medicine, University of Connecticut Storrs, Conn., Kresge Eye Institute Detroit, Mich.
  • V. EVERETT KINSEY
    School of Medicine, University of Connecticut Storrs, Conn., Kresge Eye Institute Detroit, Mich.
  • D. V. N. REDDY
    School of Medicine, University of Connecticut Storrs, Conn., Kresge Eye Institute Detroit, Mich.
Investigative Ophthalmology & Visual Science February 1965, Vol.4, 98-103. doi:
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      JOHN W. PATTERSON, MARGARETTA E. PATTERSON, V. EVERETT KINSEY, D. V. N. REDDY; Lens Assays on Diabetic and Galactosemic Rats receiving Diets that modify Cataract Development. Invest. Ophthalmol. Vis. Sci. 1965;4(1):98-103.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Cataract formation is delayed or prevented in diabetes and galactosemia by diets rich in fat and protein. This is accomplished in the presence of high levels of blood sugar and lens sugar alcohols. Diabetic rats on a high-fat diet for 235 days had lenses that were clear to the miked eye, whereas control animals developed cataracts in a median time of 65 days. The lens protein level of treated animals was about 90 per cent of normal. There was no evidence of lens swelling; however, the concentration of lens amino acids toas low.

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