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Manal Hajali, Gerald A. Fishman, Robert J. Anderson, J. Jason McAnany; Interocular Difference and Duration for Doubling of the Minimal Angle of Visual Resolution in Patients with Stargardt Disease. Invest. Ophthalmol. Vis. Sci. 2009;50(7):3374-3377. doi: 10.1167/iovs.08-2775.
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purpose. To determine the extent of interocular difference in visual acuity (VA) and the time to at least double the minimal angle of resolution (MAR) in a cohort of patients with Stargardt disease.
methods. One hundred fifty patients with Stargardt disease who were examined at least four times over a minimum period of 3 years were identified and their VA and age at each visit recorded. The maximum interocular difference of VA was determined by whether the MAR between the two eyes differed by less than a factor of 2 or by a factor of 2 or greater. Differences in maximum VA between the two eyes were also examined according to a Bland-Altman–type approach. One hundred thirty-one eyes from 76 patients were subjected to survival analysis to determine whether the time to at least double the MAR was dependent on age at baseline or starting VA.
results. Of the 150 patients, 48% had interocular MAR that differed maximally by a factor of less than 2. Thirty-five percent showed a maximum interocular difference in their Snellen VA of less than one line. The Bland-Altman– type analysis showed that maximum interocular acuity difference was dependent on the mean acuity of the two eyes. The hazard for at least doubling the MAR was related to baseline vision and patient age.
conclusions. This information has clinical significance for patient counseling and for monitoring possible benefits and patient selection in future treatment trials.
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