December 1969
Volume 8, Issue 6
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Articles  |   December 1969
The ocular immune response
Author Affiliations
  • RONALD M. BURDE
    Department of Ophthalmology, Washington University School of Medicine St. Louis, Mo. 63110
  • STEPHEN WALTMAN
    Department of Ophthalmology, Washington University School of Medicine St. Louis, Mo. 63110
Investigative Ophthalmology & Visual Science December 1969, Vol.8, 583-587. doi:
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      RONALD M. BURDE, STEPHEN WALTMAN; The ocular immune response . Invest. Ophthalmol. Vis. Sci. 1969;8(6):583-587.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Rabbits receiving an intravitreal injection of egg albumin developed immunogenic uveitis spontaneously in approximately one week. Pretreatment with systemic horse antirabbit lymphocyte serum (HARLS) was highly effective in preventing the development of the uveitis. Pretreatment with normal horse serum had no effect on the uveitis. Pretreatment with HARLS also prevented sensitization of the animal to the egg albumin as the recurrent uveitis which accompanies a later intravenous challenge of the prestimidated animal did not occur. Treatment with HARLS could not prevent the secondary response after the animal had been previously sensitized.

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