May 1970
Volume 9, Issue 5
Free
Articles  |   May 1970
Oxygen-Induced Visual Cell Degeneration in the Rabbit
Author Affiliations
  • GEORGE H. BRESNICK
    Chief, Joint Laser Safety Team, W1000, Frankford Arsenal, Philadelphia, Pa., 19137
Investigative Ophthalmology & Visual Science May 1970, Vol.9, 372-387. doi:
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      GEORGE H. BRESNICK; Oxygen-Induced Visual Cell Degeneration in the Rabbit. Invest. Ophthalmol. Vis. Sci. 1970;9(5):372-387.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

High oxygen concentrations induced visual cell degeneration in albino and pigmented rabbits. The most sensitive cells were located in the area centralis, a zone analogous to the human macula, and characterized by low glycogen content and rich choroidal blood supply. Electron microscopy demonstrated early pathological changes of intracellular membranes followed by total disorganization of visual cells, particularly those with rod-type synapses. DL-alphatocopherol acetate did not prevent visual cell damage.

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