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Sasan Moghimi, Hamid Hosseini, Jay Riddle, Gina Yoo Lee, Elena Bitrian, JoAnn Giaconi, Joseph Caprioli, Kouros Nouri-Mahdavi; Measurement of Optic Disc Size and Rim Area with Spectral-Domain OCT and Scanning Laser Ophthalmoscopy. Invest. Ophthalmol. Vis. Sci. 2012;53(8):4519-4530. doi: 10.1167/iovs.11-8362.
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© ARVO (1962-2015); The Authors (2016-present)
To compare optic disc and neuroretinal rim area measurements from spectral-domain optical coherence tomography (SD-OCT) to those from confocal scanning laser ophthalmoscopy.
Seventy-one eyes from 43 normal subjects or suspected/definite glaucoma patients were prospectively enrolled. All subjects had biometry with the IOLMaster and disc/retinal nerve fiber layer imaging with Cirrus SD-OCT (Optic Disc Cube 200×200) and Heidelberg Retina Tomograph (HRT). Uncorrected disc and rim areas and measurements corrected for eye magnification with Bennett's formula (AL-corrected measurements), along with 30° sectoral rim areas, vertical cup-to-disc ratio (VCDR), and cup volume, were compared between the two devices.
The median (range) axial length (AL) was 24.2 mm (22.4–27.7 mm). Mean keratometry-corrected HRT disc area measurements were larger than AL-corrected HRT and SD-OCT measurements (P < 0.001 for both) and the difference was a function of keratometry measurements (K-readings). The AL-corrected HRT disc area and uncorrected/corrected Cirrus disc areas were not significantly different (P > 0.481). HRT rim area was larger than Cirrus measurements (P < 0.001) and the difference decreased with decreasing rim area. HRT VCDR and cup volume were significantly smaller than Cirrus measurements (P < 0.001). The correlations for sectoral rim areas between the two devices were moderate at best (intraclass correlation coefficients = 0.12–0.65).
HRT overestimated optic disc area as compared to SD-OCT. A portion of the difference in HRT and SD-OCT disc measurements is due to HRT's magnification correction algorithm. Rim area measurements from HRT were larger than from SD-OCT, likely a result of different definitions for the reference plane and differences in disc area measurements. Disc parameters from the two devices are not interchangeable.
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