December 1975
Volume 14, Issue 12
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Articles  |   December 1975
Electrophysiologic evidence for normal optic nerve fiber projections in normally pigmented squinters.
Investigative Ophthalmology & Visual Science December 1975, Vol.14, 931-935. doi:
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      G L McCormack; Electrophysiologic evidence for normal optic nerve fiber projections in normally pigmented squinters.. Invest. Ophthalmol. Vis. Sci. 1975;14(12):931-935.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The Siamese cat, a type of albino, has a visual pathway anomaly in which too many optic nerve fibers cross at the optic chiasm, and also frequently has strabismus. The correlation of strabismus with this defect suggests that a similar pathway defect without pigmentation anomalies, may be the cause of much human strabismus. Creel, Witkop, and King have used evoked potential methods to show that such a pathway defect likely occurs in the human albino. While unpublished control experiments verified their results on human albinos, no such defect has been found in the normally-pigmented human squinter. It is concluded that the visual pathway anomaly is limited to albinism and is not a likely cause of most human strabismus.

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