February 1975
Volume 14, Issue 2
Free
Articles  |   February 1975
Quantitation of pilocarpine flux enhancement across isolated rabbit cornea by hydrogel polymer lenses.
Investigative Ophthalmology & Visual Science February 1975, Vol.14, 152-155. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      D L Krohn, J M Breitfeller; Quantitation of pilocarpine flux enhancement across isolated rabbit cornea by hydrogel polymer lenses.. Invest. Ophthalmol. Vis. Sci. 1975;14(2):152-155.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

The comparative effect on pilocarpine flux across rabbit cornea induced by two hydrogel polymer lenses containing equal doses was quantitated in a transport chamber. This closed system featured continuous flow of a tear analog but excluded variables of the internal eye influencing concentration. Flux induced by both lenses increased linearly with time. At 240 minutes total flux was a whole order greater than that induced by the same pilocarpine dose in free fluid. Analysis of pilocarpine in tear analog effluent showed the flux to be independent of the available dose retained in the hydrogel polymer lens, suggesting that corneal transport of pilocarpine to the aqueous may involve mediation by a carrier system.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×