February 1975
Volume 14, Issue 2
Free
Articles  |   February 1975
Studies on the differentiation of retinal pigmented epithelium cells in culture.
Investigative Ophthalmology & Visual Science February 1975, Vol.14, 108-113. doi:
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      G J Chader, D A Newsome, R E Bensinger, R T Fletcher; Studies on the differentiation of retinal pigmented epithelium cells in culture.. Invest. Ophthalmol. Vis. Sci. 1975;14(2):108-113.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Sephadex G-25 fractions of chick embryo extract affect the differentiation of cloned embryonic pigmented epithelial cells (PE) in culture. Both tyrosinase activity and amounts of melanin are markedly affected by the extract fractions. 5-Hydroxyindole decreased melanin accumulation in PE cells while alpha-methyl-p-tyrosine had no apparent effect on the process. Melanin disposal as well as biosynthesis may be important in controlling the accumulation of pigment in PE cells under culture conditions. Triiodothyronine greatly increased visible pigmentation and affected the morphology of cultured PE cells.

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