February 1975
Volume 14, Issue 2
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Articles  |   February 1975
Differential effects of inhibitors of monoamine oxidase Types A and B on the adrenergic system of the rabbit iris.
Investigative Ophthalmology & Visual Science February 1975, Vol.14, 155-159. doi:
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      E A Zeller, P A Knepper, D Shoch; Differential effects of inhibitors of monoamine oxidase Types A and B on the adrenergic system of the rabbit iris.. Invest. Ophthalmol. Vis. Sci. 1975;14(2):155-159.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Topical instillation of inhibitors of monoamine oxidase Types A and B into the rabbit eye, followed by the administration of a releaser of monoamines (Ro 4-1284), induces strong and sustained dilation of the iris. The mydriatic pattern differs markedly with A- and B-inhibitors and with the duration of the inhibitor treatment. The Type B inhibitor, deprenyl, prevents the degradation of exogenous 2-phenylethylamine and possibly of the endogenous amine X capable of releasing monoamines from a compartment less accessible to Ro-1284.

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