March 1975
Volume 14, Issue 3
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Articles  |   March 1975
Prostaglandin-like activity in the aqueous humor following alkali burns.
Investigative Ophthalmology & Visual Science March 1975, Vol.14, 177-183. doi:
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      C A Paterson, R R Pfister; Prostaglandin-like activity in the aqueous humor following alkali burns.. Invest. Ophthalmol. Vis. Sci. 1975;14(3):177-183.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Following application of 20 mul of 2 N sodium hydroxide to the rabbit cornea, the prostaglandin-like activity in the aqueous humor increased from undetectable levels to around 30 ng, per milliliter, a level which was sustained for up to 24 hours. This increase correlated with the previously reported sustained elevation of intraocular pressure following a 20 mul alkali burn. Pretreatment with aspirin or indomethacin virtually abolished the increase in intraocular pressure and elevation of prostaglandin-like activity in the aqueous humor following a 20 mul burn. Marked ocular hypotension following 50 mul and 100 mul sodium hydroxide burns correlated with very low prostaglandin-like activity in the aqueous humor. The low prostaglandin-like activity probably resulted from alkaline hydrolysis of aqueous prostaglandins and massive cellular death in iris and ciliary body tissues.

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