March 1975
Volume 14, Issue 3
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Articles  |   March 1975
Drugs affecting the cholinergic system in the intact mammalian eye. I. Evaluation of the miotic activity of acetylcholine-like drugs in the mouse eye.
Investigative Ophthalmology & Visual Science March 1975, Vol.14, 232-235. doi:
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      S Maayani, G Treister, M Sokolovsky; Drugs affecting the cholinergic system in the intact mammalian eye. I. Evaluation of the miotic activity of acetylcholine-like drugs in the mouse eye.. Invest. Ophthalmol. Vis. Sci. 1975;14(3):232-235.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The effect of concentration and pH on the miotic activity of five acetylcholine-like drugs were studied in the intact mouse eye. The data suggests that it is mainly the nonionized form of the drug which contributes to its miotic activity. Acetylcholine-like drugs, degradable by cholinesterases, exert their miotic activity at higher concentrations than do those which are resistant to enzymatic hydrolysis. More active acetylcholine-like drugs appear to be less sensitive to concentration changes.

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