September 1975
Volume 14, Issue 9
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Articles  |   September 1975
Adenosine 3',5'-monophosphate analogue increases the outflow facility of the primate eye.
Investigative Ophthalmology & Visual Science September 1975, Vol.14, 688-689. doi:
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      A H Neufeld, M L Sears; Adenosine 3',5'-monophosphate analogue increases the outflow facility of the primate eye.. Invest. Ophthalmol. Vis. Sci. 1975;14(9):688-689.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Our previous studies showed that cyclic-AMP increases the outflow facility of the eye of the rabbit. In this investigation, an analogue of cyclic-AMP, the 8-methylthio derivative, perfused into the anterior chamber of the eye of the vervet monkey, increased outflow facility twofold. This observation supports the hypothesis that cyclic-AMP mediates the action of adrenergic agents to reduce intraocular pressure in the primate eye.

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