April 1977
Volume 16, Issue 4
Free
Articles  |   April 1977
Experimental retinal dysplasia due to cytosine arabinoside.
Investigative Ophthalmology & Visual Science April 1977, Vol.16, 353-364. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      D H Percy, K D Danylchuk; Experimental retinal dysplasia due to cytosine arabinoside.. Invest. Ophthalmol. Vis. Sci. 1977;16(4):353-364.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Retinal dysplasia was produced in newborn rats treated postnatally with the antimitotic substance, cytosine arabinoside (ara-C). In rats examined from 6 to 60 days, there were numerous retinal rosettes surrounded by photoreceptor cells and bipolar cells containing photoreceptor cell processes, displaced nuclei, and cellular debris. Abnormal development and alignment of photoreceptor cell processes were commonly observed. Cellular degeneration was evident at all ages, and infiltrating phagocytic cells were especially numerous in the retina of treated rats examined at 60 days. Characteristic features of ara-C-induced retinal dysplasia included the scattering of bipolar cell nuclei in the inner and outer nuclear layers and marked reduction in the width of the affected retina. Considerable retinal and cerebellar development occurs postnatally in the rat, thus newborn animals might be useful in the testing of possible teratogenic drugs.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×