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R S Smith, S S Feman, L Rudt; Peroxidase permeability of the cryogenic chorioretinal adhesion.. Invest. Ophthalmol. Vis. Sci. 1977;16(9):873-877.
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Under normal conditions the retinal pigment epithelium does not permit passage of peroxidase tracers. Photocoagulation disrupts this barrier. Rhesus monkeys which received transconjunctival cryotheropy showed a similar disruption, with leakage of horseradish peroxidase into the retina. This leakage persisted for the 6-month duration of the experiment. One month after treatment, a firm chorioretinal adhesion was present, characterized by gliosis, adherent junctions, and cellular interdigitation. The anatomic features of the cryogenic chorioretinal adhesion were similar to those previously described in human eyes.
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