February 1984
Volume 25, Issue 2
Free
Articles  |   February 1984
Human anterior uvea synthesizes lipoxygenase products from arachidonic acid.
Investigative Ophthalmology & Visual Science February 1984, Vol.25, 221-223. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P S Kulkarni, A V Rodriguez, B D Srinivasan; Human anterior uvea synthesizes lipoxygenase products from arachidonic acid.. Invest. Ophthalmol. Vis. Sci. 1984;25(2):221-223.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Arachidonic acid is metabolized into biologically active prostaglandins, thromboxanes, and lipoxygenase products, leukotrienes. In the present study, the ability of human anterior uvea to synthesize lipoxygenase products from 14C-radiolabelled arachidonic acid is assessed. Following cyclooxygenase inhibition by indomethacin, human anterior uvea, similar to rabbit conjunctiva and anterior uvea, synthesizes chemotactic products 12-hydroxyeicosatetraenoic acid (HETE) and 5,12-DiHETE, indicating the presence of both 5- and 12-lipoxygenase enzyme activities.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×