August 1984
Volume 25, Issue 8
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Articles  |   August 1984
Central effects of thyrotropin-releasing hormone and arginine vasopressin on intraocular pressure in rabbits.
Investigative Ophthalmology & Visual Science August 1984, Vol.25, 932-937. doi:
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      T Krupin, G W Webb, A T Barbosa, B Gulli, J Levine, B Becker; Central effects of thyrotropin-releasing hormone and arginine vasopressin on intraocular pressure in rabbits.. Invest. Ophthalmol. Vis. Sci. 1984;25(8):932-937.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Administration of either thyrotropin-releasing hormone (TRH) or arginine vasopressin (a-VP) into the rabbit third ventricle elevated intraocular pressure (IOP). IOP was increased 3.6 mmHg 45 min after TRH (10 ng/0.1 ml) administration and increased 6.4 mmHg 45 min following delivery of a-VP (5 micrograms/0.1 ml). Outflow facility and episcleral venous pressure were not altered by either agent. Estimated aqueous humor flow 45 min after third ventricle administration was increased 66% after TRH and 91% after a-VP delivery. Posterior chamber aqueous humor ascorbate was reduced 60 min after TRH administration. Pretreatment with either systemic or topical atropine prevented the TRH or a-VP induced increase in IOP. Body temperature (BT), which was unaltered after TRH administration, was elevated by third ventricle delivery of a-VP. The a-VP induced increase in BT was blocked by systemic pretreatment with either indomethacin or atropine.

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