July 1984
Volume 25, Issue 7
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Articles  |   July 1984
Efficacy of antifungal agents in the cornea. IV. Amphotericin B methyl ester.
Investigative Ophthalmology & Visual Science July 1984, Vol.25, 851-854. doi:
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      D M O'Day, W A Ray, W S Head, R D Robinson; Efficacy of antifungal agents in the cornea. IV. Amphotericin B methyl ester.. Invest. Ophthalmol. Vis. Sci. 1984;25(7):851-854.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Quantitative mycologic techniques were used to evaluate the efficacy of topical amphotericin B methyl ester in two models of yeast infection in rabbit eyes. Doses of 1%, 0.5%, and 0.15% were used in a model of superficial Candida albicans infection. The 1% dose of drug was highly efficacious, abolishing the disease after 2 days of treatment. With doses of 0.5% and 0.15%, decreasing efficacy was observed. Antifungal activity did not deteriorate when 1% prednisolone acetate was administered concomitantly with the 1% dose. In a model of deep stromal infection, the administration of topical 1% amphotericin B methyl ester was highly efficacious when the corneal epithelium was absent. Even in corneas with intact epithelium, a reduced though still significant effect was noted.

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