October 1988
Volume 29, Issue 10
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Articles  |   October 1988
The immediate effect of phenylephrine on aqueous flow in man.
Author Affiliations
  • M M van Genderen
    Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
  • J A van Best
    Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
  • J A Oosterhuis
    Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
Investigative Ophthalmology & Visual Science October 1988, Vol.29, 1469-1473. doi:
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      M M van Genderen, J A van Best, J A Oosterhuis; The immediate effect of phenylephrine on aqueous flow in man.. Invest. Ophthalmol. Vis. Sci. 1988;29(10):1469-1473.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Aqueous flow in normal human eyes was assessed at 1 hr intervals via fluorophotometric measurements, starting 4 hr after fluorescein instillation. The average coefficients of variation of the individual flow values were 5.3% and 8.4% for 1 hr and 1 week intervals, respectively. Aqueous flow was measured in 11 healthy volunteers after the instillation of phenylephrine. In the first hour the aqueous flow showed a significant increase: 131% +/- 72% (P less than 0.001) and in the second hour: 121% +/- 92% (P less than 0.002). Between 2 and 5 hr the average flow did not differ significantly from the flow in the untreated fellow eye. There was no marked effect of pupil dilation on aqueous flow.

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