November 1988
Volume 29, Issue 11
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Articles  |   November 1988
Ocular renin-angiotensin: immunohistochemical evidence for the presence of prorenin in eye tissue.
Author Affiliations
  • S J Sramek
    Department of Ophthalmology, University of Wisconsin Medical School, Madison.
  • I H Wallow
    Department of Ophthalmology, University of Wisconsin Medical School, Madison.
  • R P Day
    Department of Ophthalmology, University of Wisconsin Medical School, Madison.
  • E N Ehrlich
    Department of Ophthalmology, University of Wisconsin Medical School, Madison.
Investigative Ophthalmology & Visual Science November 1988, Vol.29, 1749-1752. doi:
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    • Get Citation

      S J Sramek, I H Wallow, R P Day, E N Ehrlich; Ocular renin-angiotensin: immunohistochemical evidence for the presence of prorenin in eye tissue.. Invest. Ophthalmol. Vis. Sci. 1988;29(11):1749-1752.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Angiotensin II (A2) is a vasoconstrictor generated by the renin-angiotensin system. A2 appears to act also as an angiogenic factor. Recent evidence suggests that renin is synthesized at many tissue sites and may generate A2 locally. Local A2 may have important functions in the normal and diseased eye. We examined eight human eyes by immunostaining with an antibody to prorenin, the biosynthetic precursor of renin. In all eyes, prorenin staining was extensive in the pars plicata of the ciliary body suggesting that the ciliary body synthesizes renin and this renin may be part of an ocular A2 generating system.

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