November 1988
Volume 29, Issue 11
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Articles  |   November 1988
Effect of plasma osmolality and intraocular pressure on fluid movement across the blood-retinal barrier.
Author Affiliations
  • S Tsuboi
    Department of Ophthalmology, University of Minnesota, Minneapolis.
  • J E Pederson
    Department of Ophthalmology, University of Minnesota, Minneapolis.
Investigative Ophthalmology & Visual Science November 1988, Vol.29, 1747-1749. doi:
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      S Tsuboi, J E Pederson; Effect of plasma osmolality and intraocular pressure on fluid movement across the blood-retinal barrier.. Invest. Ophthalmol. Vis. Sci. 1988;29(11):1747-1749.

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Abstract

The inward permeability of the blood-retinal barrier to carboxyfluorescein was determined in monkey eyes with and without rhegmatogenous retinal detachment (RD). In the absence of changes in the diffusional permeability of the retinal pigment epithelium (RPE), inward permeability changes reflect changes in fluid flow across the RPE. Intravenous injection of mannitol resulted in a 15 mosmol/kg increase in plasma osmolality which decreased inward permeability 37% in eyes with RD and 21% in eyes with vitrectomy alone. When the intraocular pressure was raised 20 mm Hg above normal, inward permeability decreased 29% in eyes with RD and 32% in normal eyes. It is concluded that fluid flow across the blood-retinal barrier is influenced by both plasma osmolality and intraocular pressure.

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