August 1988
Volume 29, Issue 8
Free
Articles  |   August 1988
Isoproterenol treatment causes cytoskeletal reorganization in chicken lens fiber cells.
Author Affiliations
  • M E Ireland
    Department of Anatomy/Cell Biology, Wayne State University, School of Medicine, Detroit, MI 48201.
  • H Maisel
    Department of Anatomy/Cell Biology, Wayne State University, School of Medicine, Detroit, MI 48201.
Investigative Ophthalmology & Visual Science August 1988, Vol.29, 1356-1360. doi:
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      M E Ireland, H Maisel; Isoproterenol treatment causes cytoskeletal reorganization in chicken lens fiber cells.. Invest. Ophthalmol. Vis. Sci. 1988;29(8):1356-1360.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Cytoskeletal organization in organ cultured embryonic chicken lens was affected by isoproterenol treatment. Immunofluorescent localization of a 49 kD fiber cell-specific cytoskeletal protein showed a cytoplasmic and membrane localization in control lenses. Following isoproterenol treatment, fluorescence was predominantly membrane-associated. Changes in 49 kD distribution as determined by immunofluorescence occurred within minutes of isoproterenol application and were completely blocked by propranolol pretreatment. These results suggest that beta-adrenergic stimulation influences the apparent localization of a fiber cell-specific cytoskeletal protein.

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