July 1988
Volume 29, Issue 7
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Articles  |   July 1988
Acute anterior uveitis and HLA-B27 subtypes.
Author Affiliations
  • P J Derhaag
    Netherlands Ophthalmic Research Institute, Amsterdam.
  • L P de Waal
    Netherlands Ophthalmic Research Institute, Amsterdam.
  • A Linssen
    Netherlands Ophthalmic Research Institute, Amsterdam.
  • T E Feltkamp
    Netherlands Ophthalmic Research Institute, Amsterdam.
Investigative Ophthalmology & Visual Science July 1988, Vol.29, 1137-1140. doi:
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    • Get Citation

      P J Derhaag, L P de Waal, A Linssen, T E Feltkamp; Acute anterior uveitis and HLA-B27 subtypes.. Invest. Ophthalmol. Vis. Sci. 1988;29(7):1137-1140.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The tissue antigen HLA-B27 is found in 50% of Dutch acute anterior uveitis (AAU) patients. The prevalence of HLA-B27 in the normal population is only 8%. However, only approximately 1% of HLA-B27+ individuals will develop AAU. Therefore, it is possible that the disease is associated with a particular B27 subtype. We typed lymphocytes of 36 B27+ AAU patients, of which 20 also had ankylosing spondylitis, for three serologically defined B27 subtypes (B27 W, B27 K and B27 non W/non K). These subtypes were normally associated with AAU. The subtype frequencies in the patients suffering from both AAU and AS also showed no preference for a certain subtype. Subtype-specific characteristics of the primary structure of the various B27 subtype molecules therefore cannot be responsible for the disease association.

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