January 1991
Volume 32, Issue 1
Free
Articles  |   January 1991
Histamine induces endothelium-dependent relaxation of bovine retinal arteries.
Author Affiliations
  • S Benedito
    Department of Pharmacology, Aarhus University, Denmark.
  • D Prieto
    Department of Pharmacology, Aarhus University, Denmark.
  • P J Nielsen
    Department of Pharmacology, Aarhus University, Denmark.
  • N C Nyborg
    Department of Pharmacology, Aarhus University, Denmark.
Investigative Ophthalmology & Visual Science January 1991, Vol.32, 32-38. doi:
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      S Benedito, D Prieto, P J Nielsen, N C Nyborg; Histamine induces endothelium-dependent relaxation of bovine retinal arteries.. Invest. Ophthalmol. Vis. Sci. 1991;32(1):32-38.

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Abstract

The effect of histamine on bovine isolated retinal small arteries (internal diameter, approximately 240 microns) was studied. Histamine induced a concentration-dependent relaxation in 43 of 53 vessels. The histamine-induced relaxation involves primarily activation of H1-receptors, with H2-receptors also affected as evidenced by the effect of selective histamine-receptor agonists and antagonists. The histamine-induced relaxation was dependent on the endothelium and seem to involve release of both endothelium-derived relaxing factor (EDRF) and a product which was inhibited by indomethacin, probably prostaglandin I2 (prostacyclin). The development of tachyphylaxis to the action of histamine seemed to rely on desensitization of the vascular smooth muscle cells to the relaxing effect of EDRF.

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